In Vitro Models

Ready to use in vitro models that mimic the mucus layers in healthy and pathological conditions of different body districts

They come in ready to use multiwell (24 and 96) plates. The in vitro models are compatible with standard wetlab experimental practices.

They come as ready to use extrudable gels in syringes, and modified to flow into microfluidic devices and bioprinting. The in vitro models are compatible with standard wetlab experimental practices.

Select the organ of interest to check our products for determining mucus permeability and culture human microbiota.

Airway Human Mucus

Protects against airborne particles, pollutants, smoke, allergens.

Limits the diffusion of aerosolised drugs (e.g. antimicrobials, antivirals, corticosteroids, anaesthetics).

Home to microbial communities in physiological or pathological states, among which Streptococcus, Haemophilus, Staphylococcus, Pseudomonas, Klebsiella.

Check our products to determine airway permeability and culture human airway microbiota in eubiosis and dysbiosis.

Air³Gel: In vitro model for Lung Microbiota Culture

Air³Gel: In vitro model for Cystic Fibrosis Microbiota Culture

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Gastric Human Mucus

Physical protection against ingested particles.

Prevents the direct contact of digestive enzymes (pepsin) and the mucosa.

The core gastric microbiota is comprised by Prevotella, Streptococcus, Veillonella, Rothia and Haemophilus, while in pathological conditions, Helicobacter Pylori is also present.

Check our products to determine stomach permeability and culture human gastric microbiota in eubiosis and dysbiosis.

Gastro³Gel: In vitro model for Fast Stomach Microbiota Culture

Gastro³Gel: In vitro model for Fed Stomach Microbiota Culture

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Intestinal Human Mucus

The intestinal mucus houses trillions of microbes in the human gut – gut microbiota.

Protects the intestinal epithelium from coming into direct contact with bacteria, fungi and virus, thus preventing inflammatory and infection processes.

Governs the passage of microbiome-derived metabolites until these reach the intestinal epithelium.

Check our products to determine intestinal permeability and culture human gut microbiota.

Gut³Gel: In vitro model for Small Intestine Microbiota Culture

Gut³Gel: In vitro model for Colonic Microbiota Culture

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Cervicovaginal Human Mucus

Provides uterine lubrification and hydration.

Limits urinary infections and during pregnancy it is in the form of plug to prevent contamination of the foetus.

Conception regulation via alterations in mucus viscoelastic properties, affecting spermatozoa travel.

Predominantly inhabited by Lactobacilli, but also Gardnerella, Prevotella spp.

Check our products to determine cervicovaginal permeability and culture cervicovaginal microbiota.

Vag³Gel: In vitro model for Cervicovaginal Ovulatory Microbiota Culture

Vag³Gel: In vitro model for Cervicovaginal Pregnancy Microbiota Culture

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Customized Solutions

Upon order of any Bac3Gel products, whether it is a Customisable Solution, a in vitro Mucus Model or the Universal-Bac³Gel^®, the following features can be selected:

Format

- Syringe
- Multiwell plate from 6 to 96 wells
- Transwell inserts
- PAMPA membrane
- Customized format of your choosing

Culture medium

- Mueller-Hinton
- Luria Bertania
- Brain heart infusion
- Culture medium of your choosing

Additives/Supplements

- Mucin
- DNA
- Phosphatidylcholine (lipids)
- Albumin
- A supplement of your choosing

Oxygen Content

- Aerobic
- Microaerophilic
- Anaerobic

Viscoelastic Properties

- Storage modulus
- Loss modulus
- Stiffness

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